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4 edition of Regulatory properties of the mammalian adenylyl cyclases found in the catalog.

Regulatory properties of the mammalian adenylyl cyclases

by Zhengui Xia

  • 34 Want to read
  • 18 Currently reading

Published by R.G. Landes Company, Chapman & Hall in Austin [Tex.], New York .
Written in English

    Subjects:
  • Adenylate cyclase.,
  • G proteins.,
  • Cellular signal transduction.,
  • Cyclic adenylic acid.

  • Edition Notes

    Includes bibliographical references and index.

    StatementZhengui Xia, Daniel R. Storm.
    SeriesMolecular biology intelligence unit, Molecular biology intelligence unit (Unnumbered)
    ContributionsStorm, Daniel R.
    Classifications
    LC ClassificationsQP613.A33 X85 1996
    The Physical Object
    Pagination175 p. :
    Number of Pages175
    ID Numbers
    Open LibraryOL984864M
    ISBN 100412122510, 1570593604
    LC Control Number96022640

    OVERVIEW. Cyclic AMP (cAMP) and calcium (Ca 2+) are arguably the prototypical second messengers that control cellular s, for instance, nitric oxide and cyclic GMP may serve essential functions in a number of physiological situations, cAMP and Ca 2+ are the only truly ubiquitous second messengers. Significantly, it also happens that each of the Cited by: NOVEL MODULATION OF ADENYLYL CYCLASE TYPE 2 A Dissertation. Submitted to the Faculty. of. Purdue University. by. Jason Michael Conley. In Partial Fulfillment of the. Requirements for the Degree. of. Doctor of Philosophy. December Purdue University. West Lafayette, IndianaAuthor: Jason Michael Conley.

    @article{osti_, title = {Structural Basis for Inhibition of Mammalian Adenylyl Cyclase by Calcium}, author = {Mou, Tung-Chung and Masada, Nanako and Cooper, Dermot M.F. and Sprang, Stephen R and Cambridge) and Montana)}, abstractNote = {Type V and VI mammalian adenylyl cyclases (AC5, AC6) are inhibited by Ca{sup 2+} at both sub- and supramicromolar . The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca 2+.In some physiological situations, this regulation can be readily incorporated into a hormonal cascade, controlling processes such as cardiac contractility or neurotransmitter by:

      Mammalian adenylyl cyclases contain two conserved regions, C1 and C2, which are responsible for forskolin- and G-protein-stimulated catalysis. The structure of the C2 catalytic region of type II. When a signal is first transducted inside the cell, an enzyme called adenylyl cyclase is activated which converts ATP to cAMP. Then the cAMP activates protein kinase A by binding to the regulatory units in protein kinase A, thereby allowing the disassociation between the catalytic and regulatory subunits in protein kinase A.


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Regulatory properties of the mammalian adenylyl cyclases by Zhengui Xia Download PDF EPUB FB2

Additional Physical Format: Online version: Xia, Zhengui, Regulatory properties of the mammalian adenylyl cyclases. Austin [Tex.]: R.G. Landes Company ; New. Buy Regulatory Properties of the Mammalian Adenylyl Cyclases (Molecular Biology Intelligence Unit) on FREE SHIPPING on qualified orders Regulatory Properties of the Mammalian Adenylyl Cyclases (Molecular Biology Intelligence Unit): Zhengui Xia, Daniel R.

Storm: : Books. Adenylyl cyclases show differential regulation by Ca 2+ Adenylyl cyclases are regulated upon phosphorylation; Three general categories of adenylyl cyclase can be delineated based on their regulatory properties; Adenylyl cyclase is subject to long-term regulation in the nervous system.

Various aspects of mechanisms of the adenylyl cyclase (AC)* activity regulation are considered in the review. Variants of modulation of various AC isoform activity by G-proteins (αs- and αi subunits, β γ-dimer), Ca2+-calmodulin, phosphorylation by PKA, PKC or Ca2+-CM-activated kinases are presented.

Evidence is presented that AC functions as a signaling Cited by: 2. Interestingly, the catalytic domain sequence of soluble adenylyl cyclase (sAC) is more closely related to some bacterial ACs than mammalian sAC ortholog CyaC from cyanobacterium S.

platensis shares an overall active site architecture that is similar to the tmACs, but contains two cooperatively-related active addition, sACs utilize Ca 2+ rather than. Diverse Regulatory Properties The diverse structures of the adenylyl cyclases mirror the wide range of regulatory influences that impinge on them.

At one extreme, the relatively simple soluble enzyme from Streptococcus salivarius dependent on a-keto acids for activity. Completion of maturation of spermatozoa (capacitation) occurs in the female genital tract.

As a result, spermatozoa acquire the high motility and the capability for acrosomal reaction, which determines their fertility. There are evidences that adenylyl cyclase and guanylyl cyclase signaling systems detected in human and mammalian spermatozoa are involved in Author: A.

Shpakov, K. Derkach, A. Gryaznov, N. Motovilova. Novel regulatory properties of human type 9 adenylate cyclase.

Cumbay MG(1), Watts VJ. Author information: (1)Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IndianaUSA.

Nine membrane-bound members of the mammalian adenylate cyclase family have been by:   Mammalian membrane guanylyl cyclases and many microbial homologues of mammalian adenylyl cyclases are active as homodimers. The mammalian C 2 homodimer has measurable activity (9, 17, 18), although reduced by many orders of magnitude because of the loss of two catalytic Asp residues relative to the heterodimer.

Regulatory Properties of Adenylyl Cyclase Isoforms Article in Journal of Evolutionary Biochemistry and Physiology 38(4) July with 5 Reads How we measure 'reads'. The two sets of transmembrane helices of mammalian adenylyl cyclases are thus not necessary for the catalytic or the most characteristic regulatory activities of the enzyme.

Adenylyl cyclases (AC) catalyze the conversion of ATP to cAMP and pyrophosphate. There are nine different transmembrane AC isoforms activated by Gαs and each one has its own pattern of expression and regulation by calcium and other intracellular signals.

In addition, there is a soluble adenylyl cyclase, which is independent of : Maria Eugenia Sabbatini. Mammalian Class III Adenylyl Cyclases. Mammalian class III ACs have two catalytic domains, called C1 and C2.

The C1 and C2 domains are % identical, and they have low affinity for each other. C1 and C2 interact to form two distinct binding pockets at the interface. One of the pockets binds ATP and catalyzes the cyclization of ATP into cAMP.

Adenylyl cyclases occur throughout the animal kingdom and play diverse roles in cell regulation. In bacteria, the enzyme may be regulated in response to nutrients or it may constitute a toxic factor in mammals, as with adenylyl cyclases of B.

pertussis, B. anthracis, P. Adenylyl cyclases are integral membrane proteins that consist of two bundles of six transmembrane segments. Two catalytic domains extend as loops into the cytoplasm, as depicted in the figure to the right. A soluble (non-membrane bound) form of adenylyl cyclase has recently been characterized in mammalian sperm.

At least nine closely related isoforms of adenylyl cyclases (ACs), the enzymes responsible for the synthesis of cyclic AMP (cAMP) from ATP, have been cloned and characterized in mammals.

Depending on the properties and the relative levels of the isoforms expressed in a tissue or a cell type at a specific time, extracellular signals received through the G-protein-coupled receptors Cited by: Adenylyl cyclase (ECalso commonly known as adenyl cyclase and adenylate cyclase, abbreviated AC) is an enzyme with key regulatory roles in essentially all cells.

It is the most polyphyletic known enzyme: six distinct classes have been described, all catalyzing the same reaction but representing unrelated gene families with no known sequence or structural BRENDA: BRENDA entry. Analysis by us and others of both mammalian and bacterial adenylyl cyclases indicates that the release of product is random (22, 27).

This fact and the binding data permit formulation of the reaction scheme shown in Fig. Our remaining kinetic data support this mechanism and provide additional information about product release. cAMP is a key player in the intracellular signaling pathways of hormones, neurotransmitters, odorants, and chemokines.

By activating PKA and cyclic nucleotide-gated ion channels, this protean second messenger can change cellular attributes as diverse as the membrane potential and the rate of cellCited by: Search result for zhenghua-xia: Zhonghua Renmin Gongheguo Hun Yin Fa Shi Yong Zhi Nan(), Regulatory Properties of the Mammalian Adenylyl Cyclases(), Regulatory Properties of the Mammalian Adenylyl Cyclases(), Zhonghua Xian Dai Ming Ren Zhang Gu.

Adenylyl cyclases (ACs) generate the second messenger cAMP from ATP. Mammalian cells express nine transmembrane AC (mAC) isoforms (AC1–9) and a soluble AC (sAC, also referred to as AC10).

This review will largely focus on mACs. mACs are activated by the G-protein G α s and regulated by multiple mechanisms. mACs are differentially expressed Cited by: Follow Zhengui Xia and explore their bibliography from 's Zhengui Xia Author Page.activity, adenylyl cyclase activity is restored when they are mixed.

The cytosolic do-mains also retain the common regulatory properties of adenylyl cyclases (6, 8–10). We overexpressed and purified the C 1a domain from adenylyl cyclase V (VC 1) and the C 2 domain from adenylyl cyclase II (IIC 2). The apparent affinity of VC 1 for IICFile Size: KB.